Squalene, a precursor to the formation of squalane, was originally harvested from shark liver oil. This is not only an environmental concern but a safety hazard as shark-derived squalene can contain environmental pollutants and heavy metals.1 Naturium squalane is derived from sustainably sourced sugarcane and is 100% bio-based. The sugarcane goes through biofermentation using the non-pathogenic yeast. Saccharomyces cerevisae to produce Farnesene which goes through various reactions to produce squalane, bypassing the need to extract unstable squalene for hydrogenation. By pairing biotechnology with natural enzyme-catalyzed chemical reactions we obtain renewable, pure, and stable squalane with minimal impurities.2 This technology offers the highest purity squalane possible compared to other sources resulting in highly stable and efficacious squalane.

Squalane is a highly branched hydrocarbon and the saturated and stable derivative of squalene. Squalene is a main component in skin surface lipids secreted from the sebaceous glands, accounting for 13% of sebum while squalane is present in small amounts. Both oils when applied topically are proven antioxidants, soothing agents, and skin hydrators working to prevent moisture loss and smooth the skin surface. The amount of squalene drastically declines after the age of 30 resulting in increased dryness and the formation of wrinkles.3 However, squalene is a highly unstable molecule and prone to chemical oxidation and rancidity which reduces its effectiveness and therapeutic benefits when applied topically.4 Some of the oxidative by-products of squalene can cause comedogenesis, inflammation, hyperpigmentation, and wrinkling.5 Since squalane is saturated (does not contain any double or triple bonds between the carbons) it is physically and chemically stable offering better skin efficacy. Hydrogenation of squalene to squalane makes it a more skin-friendly biocompatible molecule while still preserving the skin benefits of squalene. Although it is lipophilic and considered an oil, it is noncomedogenic and biocompatible with all skin types. Clinical results show topical squalane improves moisture content, reduces appearance of wrinkles and fine lines, and enhances skin barrier integrity. Topical squalane is biomimetic as it is a naturally occurring molecule in skin and thus works for every skin type.


Lab Journals are intended to help educate on specific ingredients and skin care topics. Our articles are written to be informative and informational.
Please note any Naturium products with referenced ingredients are formulated for Cosmetic Use Only and NOT intended as replacements for physician pharmaceutical product recommendations.


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Plant Squalane Face Oil 100%


30 ML / 1.0 FL OZ Our luxurious and lightweight oil is formulated with sugarcane derived squalane that moisturizes skin for a healthier-looking com...

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