Now Reading: Azelaic Acid Vs. Retinol
Azelaic Acid Vs. Retinol

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Overall clinical data on a specific ingredient(s) & how they function.
Azelaic Acid Vs. Retinol – Which Is Right For You?
Azelaic acid and retinol are often compared for their potential to help support improvements in the appearance of skin tone and texture, and overall radiance. However, instead of debating retinol vs. azelaic acid, these two multipurpose ingredients may offer complementary benefits when used together, potentially supporting broader improvements in the appearance of acne, skin tone, and texture.
What Is Azelaic Acid?
Azelaic acid is a naturally-occurring acid, relatively gentle exfoliator, and a part of the dicarboxylic acid family. Its molecular structure differs from that of alpha-hydroxy acids (AHAs) and beta-hydroxy acids (BHAs), while its larger size generally qualifies it as a non-irritating ingredient.
It is often appreciated for its ability to help address skin congestion and uneven skin tone, specifically without leaving the skin feeling dry. It has comedolytic and antimicrobial properties that can reduce pore congestion and help reduce the look of skin redness. Azelaic acid is also categorized as an antioxidant, because it helps defend against free radicals and defend against environmental aggressors (stressors).
Can I Use Azelaic Acid If I Have Sensitive, Dry, Or Acne-Prone Skin?
Research shows that some individuals with sensitive, dry, and/or acne-prone skin will typically find azelaic acid to be a gentle, yet effective ingredient. Azelaic acid can be a positive addition to the skincare routines of anyone who is hoping to help:
- Combat skin congestion without causing the skin to look or feel irritated
- Neutralize the appearance of dark spots, including post-acne marks
- Help improve the appearance of smoother, more even skin texture and tone
- Promote a radiant-looking complexion
What Is Retinol?
Retinol is a derivative of Vitamin A and a widely known type of retinoid, offering many different benefits for various skin types.
What Skin Type Is Retinol Best For?
Some retinol formulations can be irritating for those with sensitive skin. Those with sensitive skin should start at a lower concentration and increase the dose as they build a tolerance. Incorporating hydrating or skin-soothing ingredients can help offset any potential reactivity such as peeling and redness. Some individuals may experience skin purging making the breakouts appear worse before showing signs of improvement.
Retinol is considered an ideal option for those that would like to help:
- Skin appears firmer and smoother
- Improves the look of fine lines and wrinkles
- Combat the appearance of blemishes
- Encourages radiant looking skin
- Achieve a younger-looking complexion
Is Azelaic Acid Or Retinol Better For Blemishes?
One of the most common reasons for comparing retinol vs. azelaic acid is to determine which one is best for acne-prone skin. In general, both azelaic acid and retinol can be ideal ingredients for individuals with acne-prone skin. Azelaic acid helps with the redness and uneven skin tone while retinol is known to help with congested pores that can lead to blemishes.
Can You Use Azelaic Acid And Retinol Together?
Yes, you can combine azelaic acid and retinol in your regular skincare routine. This is a great combination for those dealing with a combination of redness, aging skin, and acne-prone skin. These complementary ingredients can help address similar skin concerns, and may even provide increased support when used together, rather than alone.
How To Layer Azelaic Acid And Retinol
As a rule of thumb, the order of application should be based on the consistency of the products. Begin with thinner products (such as serums), and progress to those with thicker consistencies (such as moisturizers). If you are using both azelaic acid and retinol in the form of serums, it is not necessary to apply them in a specific order but do wait a few minutes for the first serum to fully absorb into the skin before applying the second.
Keep in mind that if you are new to these two ingredients, introducing just one at a time and patch testing is the most effective way to determine your skin’s tolerance of each.
How Often Can Azelaic Acid And Retinol Be Used Together?
Dermatologist recommend using azelaic acid up to twice a day and retinol only once daily (preferably as part of your evening routine). Because both are categorized as active ingredients, some individuals may find they prefer using azelaic acid in the morning and retinol at night. Part of this decision depends on the dosage of azelaic acid and retinol as both are offered in a variety of dosages. Azelaic acid is available up to 10% without a prescription and retinol is available up to 1% without a prescription. Regardless of how you choose to incorporate these ingredients into your daily routine, an effective sunscreen is essential.
DISCLAIMER: Lab Journals are intended to help educate on specific ingredients and skin care topics. Our articles are written to be informative and informational.
Please note any Naturium products with referenced ingredients are formulated for Cosmetic Use Only and NOT intended as replacements for physician pharmaceutical product recommendations.










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